Do you know what book this is? 这个在 中文 (简体) 里怎么说？

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@thomas1985 The other responder’s sentence is pretty good but is a broad question. There could be some better choices when you want to be extra specific.

If you want to ask the name of that book, you can also say:

你知道这本书叫什么吗？

If you want to ask the type of that book, you can also say:

你知道这是本什么类型的书吗？